Find the most important recent research around diet and familial hypercholesterolaemia
These guidelines include dietary and lifestyle recommendations and highlight that 'all people with FH should be offered individualised nutritional advice from a healthcare professional with specific expertise in nutrition'.
According to this review, diet treatment adds incremental health benefit to pharmacologic treatment in familial hypercholesterolemia.
This thematic synthesis of qualitative studies revealed several enablers and barriers to treatment adherence in individuals with FH. These could be used in clinical practice to facilitate optimal adherence to lifelong treatment thereby minimising the risk of CVD in this vulnerable population.
Although reducing the number of atherogenic apolipoprotein-B containing particle with lipid-lowering therapy represents the cornerstone of treatment of patients with inherited lipid disorders, lifestyle-related risk factors such as physical inactivity and poor diet quality need to be targeted for the optimal management of these high-risk patients.
Luiza Antoniazzi, Raquel Arroyo-Olivares, et al (2019) Association of dietary components with dyslipidemia and low-grade inflammation biomarkers in adults with heterozygous familial hypercholesterolemia from different countries. Eur J Clin Nutr doi:10.1038/s41430-019-0529-3
This multicentre, cross-sectional study of 190 familial hypercholesterolemia adults from Brazil (BR) and Spain (SP), found there was a direct association respectively of cholesterol with lipid biomarkers and of carbohydrates and trans-fatty acids with hs-CRP, while other fats showed inverse relations with the latter