Low Carbohydrate diets, Weight management, Type 2 diabetes and Dyslipidaemia
Historically, a variety of dietary patterns have been used for weight loss by Health Professionals including the Mediterranean diet, DASH diet, Vegetarian diet, Low fat diet, high protein diet and the Nordic healthy diet to name a few. Recently low carbohydrate and very low carbohydrate diets have been used for weight loss particularly been promoted for type 2 diabetes management. It has been shown that the main mode of action of low carbohydrate diets is likely to be due to the reduction in energy intake associated with carbohydrate restriction (1).
What does “low carbohydrate (low-CHO)” mean?
There is lack of clarity on what constitutes the definition of low carbohydrate (2,3). This type of diet can be defined as one containing anything between 20g and 150g carbs per day. Very low-CHO diets- 20-50g CHO daily (emphasising the replacement of CHO with fat) have become popular among lay public as well as some health professionals (4). Typically, there is little emphasis on the type of fat that replaces CHO in such diets, which may result in a high intake of saturated fatty acids and cholesterol. Furthermore, the severe restriction of CHO limits CHO intake to nonstarchy vegetables and eliminates fibre-rich starchy vegetables, as well as most fruits, pulses and wholegrains, which are foods that have been associated with reduced cardiometabolic risk (5)
Low-CHO diets, Weight Loss and Prevention of Type 2 diabetes
Weight loss is the most dominant predictor of preventing Type 2 diabetes, and it has been demonstrated that weight losses of 5-7% reduce the relative risk of Type 2 diabetes by 50% (6).Every kilogram lost is associated with a 16% relative reduction in risk (7), and losses of 10% may be sufficient to reduce the risk of future Type 2 Diabetes by 80%(8) .There is strong evidence from RCT s that intensive multicomponent lifestyle interventions incorporating diet and physical activity with sustained weight loss can prevent Type 2 diabetes in high risk individuals from different ethnic backgrounds(9-13).
A recent review by the National Lipid Association Nutrition and Lifestyle Task Force who examined the current evidence on the effects of low-CHO and very-low CHO diets for the management of body weight and other cardiometabolic factors, concluded that low-CHO and very-low-CHO diets are not superior to other dietary approaches for weight loss in the long term(14).
Overall evidence suggests that they are safe and effective over the short term for weight loss but the potential adverse effects of such a diet long term on cardiovascular risk remain unknown. Minimal data are available regarding long term (>2 years) efficacy and safety (3).
Findings from observational data has found long-term consumption of extreme CHO intakes (low and high) is associated with all-cause, cardiovascular, and cancer mortality in the general population (14)
Based on the current evidence, the key recommendations for lifestyle interventions to reduce risk of Type 2 diabetes in high risk groups include (16)
- Where appropriate, aim for weight loss of at least 5%
- Restrict energy intake to induce 5-7% weight loss
- Moderate total fat intake (<35% total energy intake)
- Reduce saturated fat intake to < 10 % total energy intake
- Increase fibre intake to >15g/1000kcal
- Increase physical activity, aiming for at least 30 mins/day or 150 mins/week of moderate to vigorous activity
- Limit alcohol intake to <14 units a week
Low-CHO Diets and Lipids
It is also important to consider what CHO foods are being replaced with, as this could shift the overall diet to one that impacts other cardiometabolic risk factors. For example, the recent Lipid Association review found that in over-weight and obese individuals, low-CHO and very-low CHO diets had mixed effects on low-density lipoprotein cholesterol (LDL-C) levels, with some studies showing an increase. A high saturated fatty acid (SFA) content was a key factor for the increase in LDL-C (14).
Due to the substantial variation in lipid responses observed in patients choosing to follow low-CHO and very-low-CHO diets, baseline and follow-up lipid profiles should be measured (14).
In terms of other lipids, compared with High Carbohydrate, Low Fat (HCLF) diets, low-CHO diets generally decrease triglyceride (TG) levels and increase HDL-C in the short term. Improvements in TG and HDL-C were achieved at low and moderate CHO intakes versus very-low-CHO intakes, which may result in better long-term adherence (14)
There may be individuals who experience extreme effects of low-CHO and very-low CHO, high fat (VLCHF) due to genetic factors. For example, patients with known hypercholesterolaemia and familial hypercholesterolaemia (FH) may have a genetic predisposition to increased LDL-C levels with VLCHF/ketogenic diets (KD). As such these diets are contraindicated.
VLCHF/KDs are also contraindicated in patients with a history of hypertriglyceridemia associated acute pancreatitis, and severe hypertriglyceridemia.
Low-CHO Diets and Management of Type 2 Diabetes
For overweight or obese adults with Type 2 Diabetes, reducing energy intake to achieve weight loss should be the primary nutritional management strategy (15). As highlighted previously, low-CHO diets can be safe and effective in the short term in managing weight in people with Type 2 diabetes. BUT based on evidence, low-CHO and very-low-CHO diets are not superior to other dietary approaches for weight loss in the long term.
Examining the effect of low-CHO or very-low CHO diets on glycaemic control, medication use and lipids in Type 2 Diabetes, the National Lipid Association Nutrition and Lifestyle Task Force review found:
- Low-CHO diets do not reduce fasting blood glucose or insulin levels more than HCLF diets in clinical trials
- Low-CHO diets result in a greater short-term reduction in HbA1c vs HCLF diets, but there were no differences between diets beyond 1 year.
- Low-CHO diets resulted in a reduction in the use of diabetes medications, and reductions in the use of diabetes medications were achieved at CHO intake levels that do not induce ketosis.
- The Mediterranean dietary pattern produced improvements in TG, HDL-C, and HbA1c levels in individuals with T2D compared with low -CHO diets
In the last few years there has been a lot of interest regarding remission of Type 2 diabetes for overweight and obese people. This appears to be related to weight loss and Diabetes UK recommend a weight loss of approximately 15 kg as as possible after diagnosis (16). A weight loss of 5% or more significantly improves HbA1c, total cholesterol-C, HDL-C, TG, blood pressure and insulin sensitivity. To maintain these benefits, it’s important the weight loss is sustained.
Evidence suggests that it is the degree of adherence that predicts outcomes rather than type of diet (16). So rather than cutting out nutrients, it is important to focus on the overall dietary pattern to ensure that the diet is balanced for obtaining and maintaining good health and one that reduces the risk of long-term conditions such as heart disease, type 2 diabetes, cancer and many other conditions.
|Results from meta-analyses suggest that there is not one macronutrient distribution superior for weight loss or for the management of Type 2 Diabetes|
|Low-CHO and very-low-CHO diets maybe an option for a short-term initial weight loss period (2-6 months) as long-term cardiovascular risk remains unknown|
|According to findings from observational studies very low-CHO diets are associated with an increased risk of mortality.|
|The decision about whether a patient should consider following a low-CHO, or very-low-CHO diet, should be made after careful discussion about the risks and benefits, as well as the patient preference. Health professionals should offer a tailored, multicomponent lifestyle intervention choosing from the variety of dietary strategies that is likely to be the most effective for that individual.|
|Due to the potential increase in LDL-C and inconsistent effects on HbA1c with low-CHO or very-low-CHO diets, close medical supervision is recommended for patients with established Atherosclerotic Cardiovascular Disease who choose to use these diets.|
|For those following a low-CHO or very-low-CHO diet, advice should be given on replacing carbohydrates with unsaturated fats, avoiding excessive intakes of saturated fat and cholesterol, as well as encouraging the consumption of appropriate vegetables, fruits, nuts, seeds, legumes, and wholegrains within the context of a CHO-restricted diet.|
|For long-term weight maintenance and cardiovascular health, emphasis should be placed on CHO foods associated with reduced cardiometabolic risk, including vegetables, fruits, wholegrains, and legumes.|
Individuals with FH and patients with a history of hypertriglyceridemia associated acute pancreatitis, and severe hypertriglyceridemia should not follow a very-low CHO, high fat diet.
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- Hamman RF, Wing RR et al. Effect of weight loss with lifestyle intervention on the risk of diabetes. Diabetes Care.2006;29(9):2102-7
- Grams J, Garvey WT. Weight Loss and the Prevention and Treatment of Type 2 Diabetes Using Lifestyle Therapy, Pharmacotherapy, and Bariatric Surgery: Mechanisms of Action.Curr ObesRep.2015;4(2):287-302
- Knowler WC, Barrett-Connor E et al; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New Engl J Med.2002;346(6):393-403
- Tuomilehto J Lindstrom J Eriksson JG et al; Finnish Diabetes Prevention Study Group. Prevention of Type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New Engl J Med.2001;344(18):1343-50.
- Pan XR, Li GW Hu YH et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care.1997;20(4):537-44.
- Ramachandran A, Snehalatha C al. The Indian Diabetes Prevention Programme (IDDP) Diabetologia.2006;49(2):289-97
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- Kirkpatrick CF, Bolick J.P et al A scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force. Journal of Clinical Lipidology August 2019
- Diabetes UK. Evidence-based nutrition guidelines for the prevention and management of diabetes March 2018
- Johnston BC, Kanters S et al. Comparison of weight loss among named diet programs in overweight and obese adults: a meta-analysis. JAMA.2014;312(9):923-33
- Ketogenic Diet and Lipids
- Non-HDL cholesterol should not generally replace LDL cholesterol in the management of hyperlipidaemia
- Enablers and barriers to treatment adherence in heterozygous familial hypercholesterolaemia: a qualitative evidence synthesis
- Diagnosis, management and prognosis of familial hypercholesterolaemia in a UK tertiary cardiac centre
- Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome
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- Pharmacological lipid-modification therapies for prevention of ischaemic heart disease: current and future options
- Current management of children and young people with heterozygous familial hypercholesterolaemia - HEART UK statement of care
- Identifying FH Using a Blood Donor Screening Program With More Than 1 Million Volunteer Donors
- Higher circulating and tissue levels of Linoleic Acid associated with lower risk of major cardiovascular events
- Substituting red meat with high-quality plant protein sources results in favourable changes in blood lipids and lipoproteins
- Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat—a randomized controlled dietary intervention study
- The Timing of Cardiovascular Health Decline and Its Association With Subclinical Atherosclerosis in Adulthood
- Is diet management helpful in familial hypercholesterolemia? Lynne Garton our Dietetic Adviser, explores.
- Statins may have a role in treating serious mental illness
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- Serum Cholesterol and Incident Alzheimer's Disease: Findings from the Adult Changes in Thought Study
- Higher intakes of fibre and wholegrains associated with lower rates of non-communicable diseases, including Cardiovascular Disease and Coronary Heart Disease.
- Risk of Ischemic Stroke and Total Cerebrovascular Disease in Familial Hypercholesterolemia May Not Be Higher
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- The effects of Vitamin D supplementation on statin adherence
- Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus: a propensity score-based analysis
- Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels
- Diabetes UK Launches new evidence based guidelines for the prevention and management of diabetes
- Effects of walnut consumption on blood lipids and other cardiovascular risk factors: an updated meta-analysis and systematic review of controlled trials
- Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials
- Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
- The complex molecular genetics of familial hypercholesterolaemia
- Parents’ views of genetic testing and treatment of familial hypercholesterolemia in children: a qualitative study
- Universal screening at age 1-2 years as an adjunct to cascade testing for familial hypercholesterolaemia in the UK: A cost-utility analysis.
- Marriage Tied to Lower Risk of Fatal Heart Attacks and Strokes
- How do the experiences and beliefs of adults and children with heterozygous familial hypercholesterolaemia influence their adherence to treatment? A systematic review of qualitative evidence protocol.
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