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Gene associated with bad cholesterol linked to early-onset Alzheimer’s disease

Researchers in the US have linked high levels of low-density lipoprotein cholesterol (LDL-C) to the risk of early-onset Alzheimer’s disease.

In the study, researchers looked at the levels of cholesterol in the blood of people with early-onset Alzheimer’s disease and healthy volunteers.

The team found that people with elevated levels of LDL cholesterol, sometimes called ‘bad’ cholesterol, are linked to the risk of early-onset Alzheimer’s disease.

Health professionals

Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat—a randomized controlled dietary intervention study

Replacing saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFAs) has been linked to a reduced risk of CVD. In addition, controlled metabolic studies have shown the importance of fat quality on LDL cholesterol and randomised controlled trials have shown that replacing SFA with PUFA significantly reduces LDL cholesterol. What is less well known is the metabolic alterations that occur when replacing SFA with PUFA in the diet.